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1 these studies could be strengthened by the use of phenformin to demonstrate that the effects of a different chemical entity with activities like metformin could be blocked by the yeast ndi1.

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In line with previous studies 15 , this effect was related to a powerful inhibition of akt activation, suggesting that the treatment with metformin could directly act on cell viability.

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Biguanides metformin target cancer stem cells.

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Metformin may lower fasting blood sugar by limiting the liver s production of glucose rather than by making cells more sensitive to insulin.

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Individuals with diabetes and this level of kidney dysfunction are at higher risk of hypoglycemia, ckd progression, and mortality compared with individuals with less severe ckd, and may particularly benefit from metformin rather than a sulfonylurea or thiazolidinedione 23,24 .

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